The best Apothecary farm that exists in the game, here is the brief introduction of the Apothecary Farming POE 3.21.
Best Strategies To Farm Apothecary In POE 3.21 | Path of Exile Apothecary Farming Guide
POE 3.21 Apothecary Farming Strategies - Lighting Arrow Build
Lighting Arrow has been one of the best magic Vine builds, especially with Mirage Archer, you are more or less playing an auto bomb or you shoot twice, you move forward, and that really keeps you out of Harm's Way, and there's not that much loot dropping in these maps and that's kind of par for the course unless until you start opening the strong boxes.
There is a little bit of a method to them Madness, and how you want to clear it and just try to go from the start of the map to the back of the map.
Some amount of profit right, but you can definitely see the map does not drop an insane amount of lube, most of your profit is going to come down to these eight mod maps and finding some currency maybe some high-value uniques.
Finally dropped the First Apothecary after 70 Maps of running Deli Mirror Crimson Temple.
Switched away from Cemetery as Apothecary Prices have finally gone up.
Mapping Costs are at an all-time high, but Scarab prices are stable as more people do Skittering Delirium Orb farm.
POE 3.21 Apothecary Farming Strategies - ATLAS
Using Wandering Path with 8 Mod Maps for the most case quantity possible
For Delirium, take nodes that help the fog dissipate slower and travel faster through the map.
Took points that helped Reward Progress as it allows us to get 7 Reward Layers
Take every Map Duplication Node, so have a 37% Chance to Duplicate Map
Take every higher Map Tier Chance Node for more Crimson Temple Drops
Put spare points into Legion Spawn Chance as Legion Pauses the Fog.
POE 3.21 Apothecary Farming Strategies - Scarabs/Sextants
Now for scares, using go to divination gilded Ambush gilded rally Quarry, and lastly Gilda Cartography.
Now if you're not running magic find, a lot of people like running Elder scareb, because Elder scareb is relatively cheap, and you can run a rusted one, and it just spawns a little bit more mobs in the map, and gives you more chances of getting that high-value drop.
POE 3.21 Apothecary Farming Strategies - Outputs and Final Tips
OUTPUTS
Maps cost on Average of 100 Chaos to Run at Current Prices. Map cost can be alleviated by selling off 8 Mod Maps as you will find a lot on every map.
High-Value Divination Cards: Seven Years Bad Luck, Enlightened, and Apothecary.
You will have a surplus of 8 Mod Maps.
With Magic Find, you will find some high-tier Uniques due to the Quantity/Rarity of Wandering Path 8 Mod Maps.
Final Tips
High Variance Strategy as you really need to find an Apothecary to make good Divine/Hr profit.
Spicysushi ended up finding a mirror before an Apothecary running a similar strategy.
Another option for Apothecary Farm is to run Defiled Cathedral and use Delirium Orbs, making us unable to use Wandering Path.
Sustain Money with Skittering and Delirium Rewards Fill Faster.
Current Awakened Sextant Prices allow new players to make bank with Searing Exarch Stream of Consciousness Farm.
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