In Diablo 2 Resurrected, the 28-Lo rune is one of the highest-level runes with a required level of 59 in the game, that can be used in socketed items to grant powerful bonuses to the character.
Specifically, when the 28-Lo rune is inserted into a socketed item, it provides +2 to all skills, +20% increased attack speed, +50% deadly strike, and prevents monster heal. It is also required in several high-level rune words, such as "Fortitude" (Lum + Ohm + Jah + Lo) and "Dream" (Io + Jah + Pul). Lo runes can also be used in combination with other high-level runes to create powerful runewords, which can provide significant bonuses to characters.
Lo runes are quite rare and difficult to obtain and are typically found in high-level areas or dropped by powerful monsters. Rune upgrading can be used to obtain Lo runes. To upgrade a lower-level rune to Lo, players need to combine it with the appropriate combination of other runes in the Horadric Cube. Here are the best areas and locations where you can try farming for Lo runes in D2R:
Hell Countess
Hellforge
Uber Tristram
Diablo Clone
Lower Kurast
Lo runes provide several powerful bonuses that can benefit a wide range of character builds in Diablo 2. Here are some popular character classes and builds that can make good use of Lo runes. Overall, any character build that focuses on physical damage, attack speed, or skill effectiveness can make good use of the Lo rune in Diablo 2. It's important to note that Lo runes are quite rare and valuable, so it's often best to use them in high-quality socketed items that can provide the most benefit.
Diablo 2 28-Lo is a Rune item in the game, and there are a total of 33 D2R Rune items on sale under this category, with prices ranging from 0.05USD to 35.9USD.
In Diablo 2 Resurrected, the 28-Lo Rune Rune can be used to create various runewords Brand, Destruction, Doom, Dragon, Fortitude, Grief, Hand of Justice*, Ice, Phoenix, Pride these can strengthen different aspects of your character. The 28-Lo Rune Rune is a versatile rune that can be used to create runewords that enhance different aspects of your character depending on your specific needs and playstyle.
PC
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XB1/SER
PC
PS4/PS5
Switch
XB1/SER
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